ICAM1 and cancer: UA mediates many of its anti-cancer effects through up-regulation of NF-ĸB [27,91,92], Bcl-2 [91], ICAM-1 [93], and PKC [94] and/or the downregulation of STAT3 [95], JNK [96], and p53 [91], resulting in apoptosis, reduced proliferation, and decreased angiogenesis thereby preventing cancer tumor formation and metastasis.