NFKB1 and Cognitive impairment: Mice fed an HFD that received a daily oral gavage of UA (10 mg/kg/day) showed reduced cognitive impairments, effects that appear to be mediated by inhibiting endoplasmic reticulum (ER) stress and the NFκB signaling pathway, and restoring insulin signaling and the mammalian target of rapamycin (mTOR) pathway [73].