An array of public neoantigens exists within a mutational hot spot encoding amino acids 175–282 within TP53, including: R248W (HLA-A*02; HLA-DRB1*13:01 in colorectal cancer); R245S (HLA-DRB3*0202 in ovarian cancer); Y220C (HLA-A*02; HLA-DRB1*04 in colorectal cancer and HLA-DRB3*02:02 in ovarian cancer) and R175H (HLA-A*02:01 and HLA-DRB1*13:01 in colorectal cancer) [118,120,131,132,133]. This evidence concerns the gene HLA-DRB1 and colorectal cancer.