Similarly, infusion of expanded TIL comprising four clonotypes directed against the public neoantigen KRAS G12D in a colorectal cancer patient induced the complete disappearance of 6 of 7 detectable lung metastases—with one lesion initially regressing then outgrowing after losing detectable expression of the restricting HLA-C*08:02 class I molecule [137]. The gene discussed is HLA-C; the disease is colorectal cancer.