IL6 and neoplasm: In the APCMin/P-sel−/− mice, we did not find a significant difference in Pten and Il6 gene expression levels and we detected a reduction in c-myc and Ccne1 gene expression levels compared to the APCMin/+ mice (Supplementary Figure S3, Figure 4G), highlighting that the absence of P-selectin reduces tumor growth after pro-carcinogenic events.