Co-regulation by YAP and E2F is confirmed in higher eukaryotes by studies on RAS-driven pancreatic cancer models: in a subset of tumors, RAS-induced oncogenic addiction is suppressed by the genetic selection of focal YAP amplification, which leads to the upregulation of E2F-dependent genes involved in cell cycle progression and DNA replication [56]. The gene discussed is YAP1; the disease is pancreatic neoplasm.