Accordingly, circular RNA circHIPK3 (hsa_circ_0000284) was shown to be upregulated in hepatocellular carcinoma (HCC), where it promotes tumorigenesis by inhibiting the tumour-suppressive activities of miR-124 [64], but it is downregulated in bladder cancer, resulting in insufficient sponging of miR-558, which promotes cancer growth through the activation of heparanase expression [65]. The gene discussed is HPSE; the disease is hepatocellular carcinoma.