In addition, the suppression of HDAC5 resulted in cell apoptosis and induced G1-phase cell cycle arrest in HCC cells by altering the levels of pro- and antiapoptotic proteins (p53, bax, bcl-2, cyto C, and caspase 3) and cell cycle regulators (cyclin D1 and CDK2/4/6). This evidence concerns the gene HDAC5 and hepatocellular carcinoma.