A number of tumor suppressor genes have also been reported to be hypermethylated in HCV-infected HCC (RASAL1, EGLN3, CSMD1, CDKN2A, BCORL1, SFRP1, ZNF382, RUNX3, LOX, RB1, and P73) [74]. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.