Hypo-fractionated radiation alsoinduces cell death by upregulating Fas and many other cytokines such as interleukin (IL)-2, IL-1α, IL-1β, IL-12, and tumor necrosis factor (TNF)-α involved in the initiation of an adaptive anti-tumor immune response [11,23,24,25,26,27,28]. The gene discussed is TNF; the disease is neoplasm.