POLE and endometrial cancer: The genomic analysis categorized endometrial cancer into subgroups based on distinct molecular characteristics: the group with DNA polymerase epsilon (POLE) somatic mutations and the corresponding ‘ultramutated’ phenotype exhibit a favorable prognosis, while the other distinct subgroups, which include tumors with microsatellite instability, low copy number, and high copy number, consist mainly of cases diagnosed as high-grade serous tumors with poor outcome.