The transition of TAMs into M2 state releases an abundant amount of transforming growth factor TGF-β, epithelial growth factor (EGF), matrix metalloproteinase MMP-2 and MMP-9, and IL-10, thus promoting tumor angiogenesis and invasion, as well as immune-suppressed microenvironment [76]. The gene discussed is TGFB1; the disease is neoplasm.