STAT3 and glioblastoma: Treatment of GBM-bearing mice with curcumin phytosome (CCP)-caused NK cells mediated the polarization of TAMs from tumorigenic M2 phenotype to tumoricidal M1 state, which was correlated with a significant reduction of M2 markers such as p-STAT3, IL-10, and Arg-1 in TAMs as well as GBM and its stem cells [210].