By contrast, expression of the V-domain Ig suppressor of T cell activation (VISTA) in PCa tissues was significantly associated with prolonged OS [26], and while expression of PD-1 or PD-L1 in pancreatic neuroendocrine tumors was rare, expression of PD-L2 was common in neuroendocrine tumor subtypes. This evidence concerns the gene CD274 and pancreatic neuroendocrine tumor.