Expression of tumor antigens MYPT1, PSMC5, and TRFR was also significantly higher in PCa tissues than in healthy controls; patients with antibodies specific for these antigens showed improved disease-free survival after granulocyte macrophage colony-stimulating factor-secreting pancreatic cancer vaccine (GVAX) therapy [62]. This evidence concerns the gene PPP1R12A and familial pancreatic carcinoma.