OLR1 (OMIM#602601) is a metabolic gene that encodes for the Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a chameleon major receptor with a key role in the development of hypertension, diabetes mellitus, hyperlipidemia, obesity and its complications [21,31]. Here, OLR1 is linked to obesity due to melanocortin 4 receptor deficiency.