In PCa tissue, Strand et al. described the candidate methylation markers PITX2, C1orf114 (CCDC181), and the GABRE~miR-452~miR-224 locus as independent predictors of biochemical recurrence, in addition to the three-gene signature AOX1/C1orf114/HAPLN3, demonstrating the potential of DNA methylation biomarkers for PCa management. Here, HAPLN3 is linked to posterior cortical atrophy.