One compound is similar to Withaferin A, which induces the down-regulation of 4 different genes (CD47, CENPB, PAQR4, SLC44A1), associated to an improved survival in uterine corpus endometrial carcinoma (CD47), brain lower-grade glioma (CENPB), kidney renal clear cell carcinoma (PAQR4), kidney renal papillary cell carcinoma (PAQR4), liver hepatocellular carcinoma (PAQR4) and pancreatic adenocarcinoma (SLC44A1). Here, PAQR4 is linked to pancreatic adenocarcinoma.