One compound is similar to Withaferin A, which induces the down-regulation of 4 different genes (CD47, CENPB, PAQR4, SLC44A1), associated to an improved survival in uterine corpus endometrial carcinoma (CD47), brain lower-grade glioma (CENPB), kidney renal clear cell carcinoma (PAQR4), kidney renal papillary cell carcinoma (PAQR4), liver hepatocellular carcinoma (PAQR4) and pancreatic adenocarcinoma (SLC44A1). This evidence concerns the gene CENPB and uterine corpus endometrial carcinoma.