ARRDC3 and neoplasm: In addition, the protein-protein interaction pattern also shows that ERGIC1 interacts with a member of the arrestin protein family (ARRDC3), which is proposed to be a breast cancer tumor suppressor [76], and with HIGD1A, which resides in mitochondria during physiological condition, and is known to be accumulated in the nuclei during severe metabolic stress or upon DNA damage [77].