TERC and breast cancer: Table 1 summarizes recent findings from cancer models with manipulation of Tert or Terc in mice or zebrafish. Supporting the aforementioned prediction, Tert overexpression in mice leads to an increased incidence of T-cell lymphomas [16], skin papillomas [17], and mammary tumors [18], depending on the promoter used to drive its expression (Table 1). Tert loss of function mutants display a delayed onset of mammary tumors [19], lymphomas [20], and early HCCs [21] (Table 1).