Certain studies indicate that the presence of CTNNB1 mutations is associated with decreased aggressiveness, invasiveness, serum α-fetoprotein levels, and more differentiated HCC [64,65,66,67,68,69], while others linked it to poorer prognosis (small vessel invasion and tumor capsule invasion) or no effect on survival [64,70]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.