NR2E3 and adrenal cortex carcinoma: Here we report for the first time on a therapeutic combination of gemcitabine (G), cisplatin (C), and the dual RNR-inhibitor COH29, which is able to strongly modulate the expression of genes coding for the RNR subunits, RNR protein abundance, RNR activity, and overall cell viability in preclinical models for ACC.