BRCA1 and breast cancer: Heterozygous pathogenic mutations of PALB2 were found in 39 probands with a mutation frequency of 1.6% among high-risk breast and 1% of ovarian cancer patients, and there was one patient with double heterozygous mutations identified in BRCA1 and PALB2. Among the single mutation carriers, the median age of breast cancer diagnosis was 39 (range 24–69) and 59 (range 36–65) for ovarian cancer mutation carriers; all of the PALB2 carriers were female (Table 2).