CD4 and neoplasm: In more detail, the TME is populated by infiltrating cells such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), endothelial progenitor cells (EPs), mast cells (MCs), mesenchymal stem cells (MSCs), T lympohocyte (CD4, CD8, CD4, Tregs), and platelets [5].