SPARC and neoplasm: Regarding the cell migration functional cluster in particular, it is interesting to observe the presence of some genes taking part in intracellular promigratory signalling pathways (ARHGAP4, GNAI2, AQP1, HSPB1) and others being implicated in the secretion of promigratory proteins (SPARC, NBL1, LGALS1), possibly acting as a chemoattractant source for the tumour cells in the neighbouring compartment.