ESRP1 is closely related to the poor prognosis of cancer patients, because ESRP1 can directly bind to the GGT-rich sequence to cut the circRNA, thereby accelerating the circRNA (such as circUHRF1 and circANKS1B) biogenesis, which in turn promotes tumor growth and metastasis [44,45]. The gene discussed is ESRP1; the disease is cancer.