This was associated with increased proliferation, motility, and invasiveness of cancer cells due to up-regulation of genes such as E-cadherin, vimentin, Bcl-2, caspases but also beta1 integrin, type 1 matrix metalloproteinase membrane (MT1-MMP), and vascular endothelial growth factor (VEGF) [142]. This evidence concerns the gene MMP14 and cancer.