Gajate et al. [132] found that edelfosine induced a caspase-mediated apoptotic response (involving activation of caspases 3, 7, 8, and 9) in pancreatic cancer cells, through the cleavage of BAP31 into p20-BAP31, alterations in the ER calcium level, and release of cytochrome c from the mitochondria to the cytosol. Here, CYCS is linked to familial pancreatic carcinoma.