In a series of recent genomic, proteomic, cell-based and mouse model studies, TYK2 has emerged as an oncogene that promotes migration, invasion and metastasis in multiple types of cancer, including stomach, MPNST, breast cancer, liver cancer, colon cancer, prostate cancer and lung cancer [14,20,22,114,115,116]. This evidence concerns the gene TYK2 and malignant colon neoplasm.