Numerous genomic rearrangements were discovered in human anaplastic large cell lymphoma (ACLC) patients with an RNAseq screen, including two fusions of TYK2 to nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (NFκB2) or poly(A) binding protein cytoplasmic 4 (PABPC4) [17]. Here, TYK2 is linked to anaplastic large cell lymphoma.