STAT1 and acute lymphoblastic leukemia: At the transcriptome level, an RNA interference (RNAi) screen engaging short hairpin RNA (shRNA) against over 1700 genes in T-cell acute lymphoblastic leukemia (T-ALL) cell lines found that TYK2 promotes cell growth and survival downstream of IL-10, through STAT1 and BCL2 signaling, while TYK2 inhibitors decreased cell proliferation [18].