In a series of recent genomic, proteomic, cell-based and mouse model studies, TYK2 has emerged as an oncogene that promotes migration, invasion and metastasis in multiple types of cancer, including stomach, MPNST, breast cancer, liver cancer, colon cancer, prostate cancer and lung cancer [14,20,22,114,115,116]. Here, TYK2 is linked to malignant peripheral nerve sheath tumor.