Other STAT target genes are involved in cancer signaling to regulate cell proliferation (e.g., cyclin D, HSP90), apoptosis (e.g., BCL-2, MCL-1, Bcl-xL), angiogenesis (e.g., VEGF-A, FGF), metastasis (e.g., MMP1-3, Vimentin, ICAM-1) and signaling (e.g., AKT, PI3K, TNF-R2) [113]. The gene discussed is BCL2; the disease is cancer.