TYK2 and acute myeloid leukemia: Furthermore, high-throughput sequencing of the kinase domains of tyrosine kinase genes identified a SNP, rs2304255 (TYK2-G363S), in the TYK2 kinase domain that was associated with acute myeloid leukemia (AML), although it is unclear as to the impact of this mutation on TYK2 function [27].