ATP6V1A and non-small cell lung carcinoma: Exploiting the ability of the lipophilic weak base ammonium chloride (NH4Cl) to neutralize the acidic endosome-lysosome system as well as the well-known capacity of the specific inhibitor of vacuolar-type H+-ATPases bafilomycin A to directly inhibit lysosomal acidification, we explored to what extent the lysosomal alkalization sufficed to abrogate the lysosomal accumulation of nintedanib in nintedanib-resistant NSCLC cells.