BRAF and metastatic neoplasm: The relevant clinical data given by gender, age, BRAF 600E mutation, LDH, CNS metastases, previous TT before the inclusion to ICI program, eosinophil counts, and NLR were initially analyzed for their risk of death due to the metastatic disease via univariate and multivariate Mantel-Cox methods (as explained in the Materials and Methods section).