Whereas, several piRNAs such as hsa-piR-54888, hsa-piR-42185, hsa-piR-46410, hsa-piR-58897, and hsa-piR-43043 were down-regulated in patients with pancreatic cancer [141], suggesting that these piRNAs could have tumor suppressive functions. This evidence concerns the gene PIR and familial pancreatic carcinoma.