Sequencing analysis showed that piRNAs including hsa-piR-52959, hsa-piR-53108, hsa-piR-30690, hsa-piR-54479, and hsa-piR-56621 were up-regulated in patients with pancreatic cancer compared to healthy people [141], suggesting the oncogenic effects of these piRNA. Here, PIR is linked to pancreatic neoplasm.