For the diagnosis of pancreatic cancer, ncRNAs in extracellular vesicles such as SNHG15, ABHD11-AS1, HULC, UFC1, circ_001569, and circ-LDLRAD3 described above could serve as diagnostic biomarkers combined with CA19-9 in liquid biopsy for better diagnosis of pancreatic cancer. The gene discussed is SNHG15; the disease is pancreatic neoplasm.