For instance we observed a RAD51C PV in a large breast/ovary family which probably only fully explains the ovarian cancer predisposition [19], and for the ATM and CHEK2 variants in six families with MS of 30–39 and one CHEK2 in a MS of >40, these are unlikely to provide a full explanation for the pattern of disease in these families (Table 1) [11]. The gene discussed is CHEK2; the disease is ovarian carcinoma.