TP53 and breast cancer: Of the other high-risk genes there were 10 TP53, one CDH1 and one PTEN PVs, but none in STK11. All the expected breast cancer associated genes (ATM, CHEK2, PALB2, TP53) had significantly increased odds ratios of above 2-fold compared to the 1443 PROCAS control samples (Table 1).