Although this was a small study (n = 224; 61 PVs-19 BRCA1/2) and the association was likely driven primarily by BRCA1/2. The BRIDGES study did not assess grade, but there was a clear association between RAD51C, RAD51D, PALB2 and BARD1, with ER− breast cancer and ATM and CHEK2 with ER+ breast cancer with no association of ATM with ER− [16]. This evidence concerns the gene ESR1 and breast carcinoma.