In fact, similar to G3-WD-NETs [27], the majority of non-SC EP-NECs with a Ki-67 index of <55% from the present study were of pancreatic origin (52.2%) (Other sites of origin were stomach (13.0%), CUP (8.7%), colon (8.7%), small bowel (8.7%), ovary (4.3%) and biliary tract (4.3%)). This evidence concerns the gene MKI67 and Wilson disease.