Lamarca et al. [26] developed a combined prognostic score for patients with GEP-NEC including five variables, i.e., presence of liver metastases, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), ECOG PS and Ki-67 (≤80% vs. >80%). This evidence concerns the gene MKI67 and neuroendocrine carcinoma.