Colon cancer samples from the TCGA showed high expression of CXCL1, 3, 5, 6, and 11 and low expression of CXCL12 (fold change > 2); the Bittner poly-cancerous dataset confirmed the differential expression of CXCs in colon cancer and breast cancer. Here, CXCL12 is linked to malignant colon neoplasm.