TNF and Legionnaires' disease: In KEGG analysis, the main enriched signal pathways were as follows: hsa04060: cytokine–cytokine receptor interaction; hsa04062: chemokine signal pathway; hsa05323: rheumatoid arthritis; hsa04668: tumor necrosis factor signal pathway; hsa04620: Toll-like receptor signal pathway; hsa05144: malaria; hsa04621: node-like receptor signal pathway; hsa05132: Salmonella infection; hsa05321: inflammatory bowel disease (IBD); and hsa05134: Legionnaires’ disease (Figure 14E).