Interestingly, the genes coding for chemokines such as CXCL1, CXCL2, CXCL3, and CXCL8 (IL-8) were strongly upregulated in CD4+ T cells co-cultured with cancer cells only, further suggesting the direct influence of cancer cells on chemokine expression in CD4+ T cells. This evidence concerns the gene CD4 and cancer.