The global transcriptomic analysis of restimulated CD4+ T cells grown with cancer cells compared to restimulated CD4+ T cells grown without cancer cells revealed that CD4+ T cells in contact with cancer cells overexpressed the chemokine and other cytokine-encoding genes, such as the CXCL family and interleukins IL-6, IL-1B, and IL-8, which may be secreted to the tumor microenvironment (TME). This evidence concerns the gene IL1B and neoplasm.