In the present study, the median (the range) of serum DJ-1 levels in colorectal cancer patients with TNM stage I (n = 24), II (n = 18), III (n = 18), and IV (n = 23) were −0.2938 (−1.2017–3.6186) ng/mL, 0.2996 (−0.3035–1.4701) ng/mL, 0.8508 (−0.3943–3.5064) ng/mL, and 1.1621 (0.2153–7.0042) ng/mL, respectively. This evidence concerns the gene PARK7 and colorectal cancer.