Several blood markers are used for the diagnosis and prognosis of colorectal cancer, e.g., carcinoembryonic antigen (CEA), carbohydrate antigen (CA 19.9), tissue polypeptide specific antigen (TPS), tumor-associated glycoprotein-72 (TAG-72), hematopoietic growth factors (HGFs), macrophage-colony stimulating factor (M-CSF), granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin-3, interleukin-6, alcohol dehydrogenase, and lysosomal exoglycosidases, but none of these tests have excellent diagnostic accuracy and all of that with significant limitations [44]. This evidence concerns the gene AKR1A1 and colorectal cancer.