In lung carcinoma cells, GO sheets conjugated with the lysosomal inhibitor chloroquine caused excessive accumulation of autophagosomes, with p62 and ATG5 serving as scaffolds for necrosome assembly and subsequent execution of necroptosis by necrosome components receptor-interacting protein kinases 1/3 and mixed lineage kinase domain-like protein [43]. The gene discussed is ATG5; the disease is lung carcinoma.