This is the case of FLT3, DNMT3A and NPM1 [56,57], and of other recurrent mutations such as IDH1/2 or CEBPα. Similarly, spliceosome and epigenetic proteins such as SF3B1 and TET2, which are found among the most frequently mutated proteins in myelodysplastic syndromes (MDS), are only mutated in less than 3% of cases in ML-DS. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.