Natural compounds that may synergize with conventional cancer therapies, such as Sageretia thea extracts, Ginnalin A (red maple), and fisetin (strawberries), have been shown to decrease cancer cell viability and inhibit colony formation and cell migration in CRC and metastatic breast cancer due to mechanisms of HO-1 upregulation via Nrf2 [45,76,77,78]. This evidence concerns the gene NFE2L2 and cancer.