HP and Schnyder corneal dystrophy: However, induction of CO/HO-1 by these heme scavengers can inhibit hemoglobin and heme-mediated microvascular stasis in SCD hyper hemolytic mouse model, which suggests that hemoglobin-heme-dependent vaso-occlusive crisis (VOC) and chest syndrome in SCD patients can be prevented by Hp and Hx supplementation [256].