Natural compounds that may synergize with conventional cancer therapies, such as Sageretia thea extracts, Ginnalin A (red maple), and fisetin (strawberries), have been shown to decrease cancer cell viability and inhibit colony formation and cell migration in CRC and metastatic breast cancer due to mechanisms of HO-1 upregulation via Nrf2 [45,76,77,78]. The gene discussed is HMOX1; the disease is cancer.