P53 suppresses tumorigenesis and regulates tumor chemoresistance through transcriptional regulation of diverse genes that encode for proteins, such as cyclin-dependent kinase inhibitor p21, which is essential for G1 arrest induced by DNA damage [177], apoptosis regulator Bax [178], and hypoxia central regulator HIF that is involved in tumor angiogenesis [179]. This evidence concerns the gene TP53 and neoplasm.