HK2 and non-small cell lung carcinoma: In oncogene-driven non-small cell lung cancer (NSCLC) we have previously shown that inhibition of the oncogene driver by TKIs causes a metabolic switch from glycolysis to oxidative phosphorylation through the concerted downregulation of HKII and p-PKM2Tyr105 and upregulation of OXPHOS [20,21].