Immunosuppressive lymphocytes, including regulatory T cells (Treg cells), tumor-associated macrophages, myeloid-derived suppressor cells, cancer-associated fibroblasts, and tolerogenic dendritic cells, suppress the activity of NK cells by secreting immunosuppressive products (TGFβ and metabolites) or disrupt the interaction between NK cells and cancer cells through competition or misleading decoy [54]. The gene discussed is TGFB1; the disease is neoplasm.