TLR4 and neoplasm: For the tumor suppressor genes BRCA1, RUNX3, PAX6, GALNT9, SIM1, and FBLN2 [26,35,39,40,41,42], decreased methylation as a result of exercise was hypothesized; for the oncogenes AURKA, BCAR1, and BPIF4AP/BASE [37,38,43], increased methylation as a result of exercise was hypothesized; and for the inflammation Toll-like receptor genes TLR4 and TLR6, increased methylation as a result of exercise was hypothesized [23,26].