IL18 and breast carcinoma: We were able to find only one similar randomized experiment in the literature [49], and though the findings provided support for a causal role of exercise on methylation of the ASC gene (responsible for IL-1β and IL-18 secretion), the participants were older (mean age ~65), methylation data were only obtained post-exercise intervention so change could not be assessed, and the genes explored were not related to breast cancer.