Meanwhile, high expression of C3, C5, C3AR1, and C5AR1 is associated with worse PDL1 outcomes in bladder cancer (ICB_Mariathasan2018_PDL1) and PD1 (ICB_Gide2019_PD1) and ACT (ICB_Lauss2017_ACT) outcomes in melanoma and treatment-naïve melanoma treated with ICB (ICB_Riaz2017_PD1 Ipi_Naive) (Figure 6A, second panel). This evidence concerns the gene C3AR1 and melanoma.