C3AR1 and cancer: According to the variant classification, a missense mutation is the most prevalent SNV of C3, C5, C3AR1, and C5AR1 in TCGA cancer cohorts (Figure 3B). Specifically, the majority of the C3, C5, C3AR1, and C5AR1 mutations transitioned, including the C > T and T > C transitions followed by the C > A transversion (Figure 3B).