Furthermore, the T-cell dysfunction phenotype is associated with differential methylation levels of C5 in brain, breast, cholangio, kidney, leukemia, liver, lung, stomach, and uveal cancer; C3 in bladder, brain, endometrial, esophageal, liver, lung, melanoma, pancreatic, sarcoma, stomach, and uveal cancer; and C3AR1 in bladder, colorectal, endometrial, liver, melanoma, pancreatic, and uveal cancer. Here, C3 is linked to melanoma.