C3 and familial pancreatic carcinoma: Interestingly, we found a strong association between T-cell dysfunction phenotypes and CNVs of C5 in breast, colorectal, endometrial, head and neck, and ovarian cancer; CNVs of C3 in brain, endometrial, head and neck, liver, and pancreatic cancer; CNVs of C3AR1 in breast, cholangitis, kidney, head and neck, and pancreatic cancer; and CNVs of C5AR1 in colorectal, head and neck, liver, and melanoma cancer.