NOS2 and brain neoplasm: Moreover, 93.2% of the M1-like phenotype (iNOS + Iba1+) microglia/Mφ distribution ratio in brain tumor tissues was significantly increased in the dLGG–10 mice compared to the tumor control (17%), Lipo-DOX–2 (49%), and dLGG–10 + Lipo-DOX–2 (33.4%) mice (Figure 3b).