For instance, 12(S)-HETE and 15(S)-HETE derived from arachidonic acid (AA) by 12/15-LOX increase B16F10 melanoma cell adhesion and lung metastasis through activating the ERK and FAK signaling pathways [18]; CYP450-4A produced from TAMs with M2 phenotype promoted pre-metastatic niche formation and cancer metastasis in a 4T1 breast cancer and B16F10 melanoma spontaneous metastasis mouse model [19]. Here, PTK2 is linked to melanoma.