The expression levels of both 15-LOX and CYP450-4A proteins from either melanoma (Mel-A+) or microglia/Mφ (F4/80+) in the TME of dLGG–10- and dLGG–10 + Lipo-DOX–2-treated mice were lower than those in the tumor control mice. This evidence concerns the gene ALOX15 and melanoma.