The results in Figure 4e show that 15-LOX and CYP450-4A were produced by both microglia/Mφ (F4/80+) and melanoma (Mel-A+) in brain tumor tissues; among them, the melanoma cells detected with 15-LOX+ (Mel-A+/15-LOX+) and Mφ with 15-LOX+ (F4/80+/15-LOX+) were 364 ± 17 cells and 190 ± 6 cells, respectively, higher than CYP450-4A+ cell populations (Mel-A+/CYP450-4A+; 253 ± 15 cells, F4/80+/CYP450-4A+; 157 ± 6 cells). This evidence concerns the gene LOX and melanoma.