ALOX15 and neoplasm: Next, we examined the protein expression profile of 15-LOX and CYP450-4A (its metabolite 20-HETE was the most significantly inhibited by dLGG; 3-fold) in the brain TME of the tumor control, dLGG–10, Lipo-DOX–2 and dLGG–10 + Lipo-DOX–2 mice (n = 3 in each group) by IHC.