Moreover, FREM2 pathway activation level (PAL) could effectively predict survival within the subgroups with different IDH mutation statuses: OS in IDH mutant LGG, and PFS in IDH mutant GBM, in LGG with wtIDH, and LGG with mutant IDH. Furthermore, activation levels of the FREM2 pathway were significantly higher in GBM than in LGG samples. Here, FREM2 is linked to glioblastoma.