As miR146a was previously shown to regulate EGR1 [61], we analyzed the miR146a expression in NHEM and five melanoma cell lines from the primary tumor (Mel Juso, Mel Wei, WM3211) and metastasis (Mel Im, SkMel28) by qRT-PCR and confirmed its downregulation in melanoma compared to melanocytes (Figure 5E) [18,62]. The gene discussed is EGR1; the disease is neoplasm.