Cytokine profiling with measurement of serum levels of the proinflammatory cytokines interleukin-5 (IL-5), IL-6, interleukin-10 (IL-10), interleukin-17A (IL-17A), interferon-gamma (IFN-g), monocyte chemoattractant protein 1 (MCP-1), and tumor necrosis factor alpha (TNF-a) in patients who developed CRS after CD3-engaging bispecific antibody APVO436 indicates that the predominant cytokine in this inflammatory cytokine response is IL-6 [58]. This evidence concerns the gene TNF and congenital rubella syndrome.