Recently, a phase I study evaluating the safety and pharmacokinetics of YM155 in combination with erlotinib in patients with EGFR TKI refractory advanced NSCLC demonstrated a favorable safety profile and moderate clinical efficacy when YM155 was administered up to 8.0 mg/m2/day every three weeks [109]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.