The two groups were comparable in terms of DCIS tumor grade (p = 0.797), DCIS architecture pattern (p = 0.084), DCIS tumor size (p = 0.117), tumor necrosis area (p = 0.912), IDC tumor grade (p = 0.165), ER status (p = 0.458), PR status (p = 0.340), HER2 status (p = 0.647), and Ki67 (p = 0.873). This evidence concerns the gene ESR1 and ductal breast carcinoma in situ.