PLAU and neoplasm: Overexpression of components of the uPA system (uPAS) in GOCs, on tumour cells and/or associated stromal cells in the tumour microenvironment (TME), is strongly associated with worse tumour staging [17,18,19,20], clinicopathological features [21,22,23,24,25,26,27] and reduced patient survival [12,17,18].