For instance, the epithelial to mesenchymal transition (EMT)-regulators zinc finger E-box- binding homeobox-(ZEB)-1 and -2, snail family transcriptional repressor 2 (SLUG), snail family transcriptional repressor 1 (SNAI1) and TWIST-related protein 1 (TWIST) are critical drivers of tumor progression [3,4]. This evidence concerns the gene TWIST1 and neoplasm.