CTLA4 and neoplasm: Indeed, these animals at 8 weeks of age show a coarse liver surface, immune infiltration, and mild fibrosis at this young age, which spontaneously resolves over time (32 weeks of age) (Figure S1A), in line with the normalization in the expression of the ER stress marker Ddit3, serum ALT, and Srebpf2 and Col1a1 (Figure S1B–E), as well as the genes involved in inflammation (Tnfα); tumor markers (Afp, Birc5, and Golm 1); and the immune checkpoint (Ctla4, Endtpd2, and IghA) (Figure S1F–H).