In parallel with these findings, DEN administration increased the expression of HCC and HIF-1α markers in rats fed the ATH diet with respect to CD feeding, including Afp and Vegf-α, as well as the expression of STARD1, which has been recently shown to promote NASH-driven HCC [10] (Figure 1G). This evidence concerns the gene VEGFA and metabolic dysfunction-associated steatohepatitis.