In similar models, LD-Vel was shown to augment activation signals in CD8+ T cells such as PI3K/Akt/STAT5 pathways and to significantly increase production of the immunostimulatory cytokines IL-2, IL-12, and IL-15 while decreasing the levels of tumor-promoting cytokines IL-1β and VEGF [101]. Here, CD8A is linked to neoplasm.