CLU and neuroblastoma: More recently, analysis of global gene and miRNA expression in human neuroblastoma cells treated with Vel [85] revealed changes in expression of over 1000 genes and 89 miRNAs, including significant upregulation of genes engaged in apoptosis, such as clusterin (CLU), heme oxygenase (decycling) 1 (HMOX1), caspase 7, and DNA-damage-inducible transcript 3 (DDIT3).