CD4 and neoplasm: In solid tumor mouse models, Shanker et al., reported that low dose Vel (LD-Vel) had no significant effect either on total leukocyte counts or on the levels of CD4+ or CD8+ T cells in either control or tumor-draining lymph nodes, spleen, or tumor-infiltrating lymphocytes, whereas a high-dose regiment led to leukopenia and an increased number of lung metastases [100].