One of the consequences of the CRBN–E3 ligase interaction is augmentation of the selective ubiquitination and degradation of two transcription factors, IKZF1 and IKZF3, and the subsequent loss of interferon regulatory factor 4 (IRF4) and MYC expression found to be essential for myeloma cell proliferation [63]. The gene discussed is IKZF3; the disease is plasma cell myeloma.