In order to investigate the role of p53 degradation for YAP/TAZ upregulation, we selected three cell lines based on their p53 status: human epidermal keratinoctyes (HEKn, wild-type p53), C33A cervical cancer cells (mutated p53), and H1299 lung cancer cells (p53-null). The gene discussed is TP53; the disease is cervical carcinoma.