TP53 and neoplasm: In breast cancer, p53-R175H, p53-R273H, or p53-R280K interacts with HIF-1α, and transcriptionally upregulates miR-30d, which causes the enhancement of vesicular trafficking and secretion, leading to the remodeling of the extracellular matrix and the establishment of a microenvironment suitable for tumor growth and metastasis [38].