TP53 and prostate carcinoma: However, p53-R175H additionally upregulates developmental genes, including EMT regulator gene TWIST1. p53-R175H increases the expression of TWIST1 by downregulating BMI-1, which maintains the level of epigenetic repression marker H3K27me3, causing the epithelial–mesenchymal transition and invasion of prostate-cancer cells [39].