WIPF1 and cancer: In human astrocytes overexpressing p53-R175H, AKT2 that is activated by p53-R175H phosphorylates the WASP interacting protein (WIP), and the phosphorylated WIP stabilizes the YAP/TAZ complex, causing the transcriptional activation of genes that promotes cancer-stem-cell survival, including CYR61, CTGF, BIRC5 (also known as SURVIVIN), and CAV2 [46].