TP53 and colorectal cancer: In colorectal cancer, p53-R175H, p53-R248W, and p53-R273H can bind to SUMO-specific protease 1 (SENP1) and inhibit its de-SUMOylation function, causing the accumulation of SUMOylated Rac1, which is an activated form of RAC1 that promotes tumor growth and metastasis [41] (Table 4).