KLK3 and posterior cortical atrophy: As reported before, a combination of biomarkers [26], such as the MiPS (Mi Prostate Score Urine test), which contains serum PSA, urinary PCA3 and TMPRSS2-ERG (transmembrane protease, serine 2, v-ets erythroblastosis virus E26 oncogene like), could provide a higher accuracy for high-grade PCa than the PSA alone (AUC: 0.729 vs. 0.651, p < 0.001) [27].