SPDEF and posterior cortical atrophy: Furthermore, another research developed an assay called ExoDx Prostate (IntelliScore) (EPI), which contained three urinary exosome genes (PCA3, ERG and SPDEF (SAM pointed domain-containing Ets transcription factor)) to improve the diagnosis of high-grade PCa (AUC: 0.77) and avoid unnecessary biopsies [29].