The AUC analysis showed that the lncRNA assay combining the PCA3 score and the MALAT1 score yielded an AUC of 0.831, which was much higher than that of PCA3 (0.831 vs. 0.723, p < 0.001), to distinguish clinically significant PCa from nonaggressive diseases. Here, MALAT1 is linked to posterior cortical atrophy.