When comparing more severe (eGFR < 60 mL/min/1.73 m2) to milder (eGFR ≥ 60 mL/min/1.73 m2) kidney dysfunction, the most relevant factors accompanying decreased function were co-existing diabetes mellitus, arterial hypertension, hyperlipidemia, elevated levels of uric acid, leukocytes, neutrophils, monocytes, LDH, CRP, and MPN therapy (Table 2). This evidence concerns the gene CRP and Hypertension.